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KMID : 0882420140860010084
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Korean Journal of Medicine
2014 Volume.86 No. 1 p.84 ~ p.88
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A Case of Different Organ Responses to Immunosuppressive Therapy In a Microscopic Polyangiitis Patient with Interstitial Lung Disease
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Lee Jae-Joon
Shin Jong-Ho
Bang Ki-Tae
Choi Ji-Wook
Moon Hyun-Jin
Jeon Jae-Woong
Jeong Jin-Uk
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Abstract
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Microscopic polyangiitis (MPA) is an idiopathic autoimmune disease characterized by systemic vasculitis associated with antineutrophil cytoplasmic autoantibodies. Interstitial lung disease is a less recognized manifestation of MPA and has a poor prognosis. A 61-year-old man presented with persistent cough, sputum and dyspnea. Laboratory examination revealed microscopic hematuria and renal insufficiency. Perinuclear anti-neutrophil cytoplasmic autoantibodies were positive according to serological testing. Computed tomography scans showed bibasilar reticulation and honeycombing in a peripheral distribution. Therefore, renal biopsy was performed, and MPA was diagnosed. After treating with corticosteroids and immunosuppressive agents, the patient had a complete renal response but progressive interstitial lung disease. We report a case of MPA presenting with interstitial lung disease in which the patient experienced different responses in each organ.
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KEYWORD
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Microscopic polyangiitis, Interstitial lung disease, Anti-neutrophil cytoplasmic antibody-associated vasculitis
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